ABSTRACT
Objective:To explore clinical characteristics, diagnosis and treatment of pulmonary tuberculosis (TB) after lung transplantation (LTx).Methods:Between March 2017 and December 2021, 17 TB infections were diagnosed in 424 LTx recipients at China-Japan Friendship Hospital.Clinical data were retrospectively reviewed and clinical features, treatments, therapeutic efficacies and outcomes examined.Results:The incidence of TB was 4%(17/424). There were 14 males and 3 females, with a median age of 57 years.Bilateral LTx was performed (n=12). Eight probably donor derived infection, six de novo exposure and infection and 3 reactivation of latent tuberculosis infection (LTBI) of recipients were determined.Most infections (16/17) were diagnosed within the first year post-LTx and 11 infections within the first month.All 17 cases were TB DNA positive and one positive for rifampin-resistant gene.Four cases were positive for TB DNA and acid-fast bacilli test and 6 cases positive for TB DNA and culture.Nodular or cavity (10/13) was the most common finding on chest tomography and the lesions were located predominantly in superior lobe.Therapeutic regimen without rifamycin (n=14) and rifabutin or rifapentine replacing rifampin (n=2) were employed.Treatment was successful (n=10) and clinically effective (n=2). Only one TB infection related death was recorded.Conclusions:LTBI or donor derived infection is common.Therapeutic regimen without rifamycin shows some potential clinical feasibility.
ABSTRACT
In this study,we invertigated the amounts of fish consumption,determined the content of mercury in hairs,useda way of increasing excretion of mercury,estimated the level of retention of methylmercury,analysised the pattern of excretion of methylmercury,of fishers and farmers on Zhao Yuan country Hei Long Jiang Province.As a result,It was foundthat average value of methylmercury in fisher hairs was 2.50 PPm,the contents of daily intake of methylmercury was 69.09?g,the contents of excretion of methyl-mercury in urine was the highest,it wag 13.62?g/24hr,methylmercury in urine increased 42.41 times,and the increased figure was the highest among all sorts of ways of excretion.The study also showed that the curve of excretion had twopeaks,They appeared in the first and 6th day,and which would be discussed.